| ncRNA name | PKA siRNA |
| ncRNA Category | siRNA |
| Disease name | uveal melanoma (UM) |
| Species | Homo sapiens |
| Tissues/Cell_line | human UM cell line 92.1, Mel270, OCM-1 and TP31 |
| Methods | flow cytometry, clonogenic assay, PCR, Western blot, siRNA transfection |
| Expression pattern | associated |
| Functional description | Pharmacological inhibition of cAMP-dependent protein kinase (PKA) and siRNA-mediated depletion of PKA greatly reduced B-Raf activity, ERK1/2 activation, and cell proliferation in (WT)B-Raf cells. |
| PubMed ID | 16452469 |
| Year | 2006 |
| Title | Extracellular signal-regulated kinase-dependent proliferation is mediated through the protein kinase A/B-Raf pathway in human uveal melanoma cells. |
| Drug-related ncRNA | NO |
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